There are crystals in my GOPOD reagent buffer. Is this normal and will it affect my assay?

Crystallization of the GOPOD reagent buffer may occur, this is not unusual for concentrated solutions stored at 4°C. This will not affect the performance of the kit. Leaving the buffer at room temperature for approximately 30 mins before making up the solution should result in a significant reduction of the crystals formed. You need to ensure that the crystals are transferred and completely dissolved when this buffer is diluted to 1 L with distilled water.